DETAILS, FICTION AND LDN-27219 DRUG DEVELOPMENT PIPELINE

1 significantly interesting compound is LDN-27219. Though most tTG inhibitors are built to bind on the protein crosslinking active web page, LDN-27219 as an alternative binds towards the nucleotide binding pocket of your enzyme even though it really is in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activi